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SereniCare Vet Technical Detailer References

Smarter pet care, powered by biotics. SerniCare is a calming support supplement for dogs and cats, containing a novel blend of ingredients to help manage stress, anxiety and gut health.
  1. Appleton J. The gut-brain axis: influence of microbiota on mood and mental health. Integr Med (Encinitas) 2018; 17(4): 28-32.
  2. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 2015; 28(2): 203-209.
  3. Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients 2016; 8(1): 56.
  4. Chen Y, Xu J, Chen Y. Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders. Nutrients 2021; 13(6): 2099.
  5. Gao K, Mu CL, Farzi A, Zhu WY. Tryptophan metabolism: a link between the gut microbiota and brain. Adv Nutr 2020; 11(3): 709-723.
  6. Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-tryptophan: basic metabolic functions, behavioral research and therapeutic indications. Int J Tryptophan Res 2009; 2: 45-60.
  7. Waclawiková B, El Aidy S. Role of microbiota and tryptophan metabolites in the remote effect of intestinal inflammation on brain and depression. Pharmaceuticals (Basel) 2018; 11(3): 63.
  8. Dehhaghi M, Kazemi Shariat Panahi H, Guillemin GJ. Microorganisms, tryptophan metabolism, and kynurenine pathway: a complex interconnected loop influencing human health status. Int J Tryptophan Res 2019; 12: 1178646919852996.
  9. Kaur H, Bose C, Mande SS. Tryptophan metabolism by gut microbiome and gut-brain-axis: an in silico analysis. Front Neurosci 2019; 13: 1365.
  10. Gheorghe CE, Martin JA, Manriquez FV, Dinan TG, Cryan JF, Clarke G. Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis. Curr Opin Pharmacol 2019; 48: 137-145. 
  11. Reigstad CS, Salmonson CE, Rainey JF et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J 2015; 29(4): 1395-1403.
  12. Lv J, Liu F. The role of serotonin beyond the central nervous system during embryogenesis. Front Cell Neurosci 2017; 11: 74.
  13. Nuss P. Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatr Dis Treat 2015; 11: 165-175.
  14. Tillakaratne NJ, Medina-Kauwe L, Gibson KM. gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp Biochem Physiol A Physiol 1995; 112(2): 247-263.
  15. Griffin CE 3rd, Kaye AM, Bueno FR, Kaye AD. Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J 2013; 13(2): 214-223.
  16. Salminen S, Collado MC, Endo A, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol 2021; 18: 649-667
  17. Data on file
  18. Martorell P, Alvarez B, Llopis S, et al. Heat-treated Bifidobacterium longum CECT-7347: a whole-cell postbiotic with antioxidant, anti-inflammatory, and gut-barrier protection properties. Antioxidants (Basel) 2021; 10(4): 536.
  19. Miclo L, Perrin E, Driou A, Papadopoulos V, Boujrad N, Vanderesse R, Boudier JF, Desor D, Linden G, Gaillard JL. Characterization of α?casozepine, a tryptic peptide from bovine αs1?casein with benzodiazepine?like activity. FASEB J 2001; 15(10): 1780-1782.
  20. Ceraudo G, Sonia C, Lavinia R, Dell’Osso B, Liliana D. Short-term anxiolytic and pro-hypnotic activity of a tryptic hydrolysate of bovine αs1-casein in patients with anxiety spectrum disorders. Journal of Nutraceuticals and Food Science 2017; 2(2): 1-5.
  21. Beata C, Beaumont-Graff E, Coll V, et al. Effect of alpha-casozepine (Zylkene) on anxiety in cats. J Vet Behav 2007; 2(2): 40-46.
  22. Beata C, Beaumont-Graff E, Diaz C, et al. Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. J Vet Behav 2007; 2(5): 175-183.
  23. Violle N, Messaoudi M, Lefranc-Millot C, Desor D, Nejdi A, Demagny B, Schroeder H. Ethological comparison of the effects of a bovine alpha(s1)-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety. Pharmacol Biochem Behav 2006; 84(3): 517-523.
  24. Messaoudi M, Bresson J-L, Desor D, Lefranc C, Boudier J-F, Paquin P. Anxiolytic-like effects of the milk protein hydrolysate Lactium® in healthy human volunteers. Stress 2002; 5 (suppl.): 124.
  25. Messaoudi M, Lefranc-Millot C, Desor D, Demagny B, Bourdon L. Effect of a tryptic hydrolysate from bovine milk αs1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations. Eur J Nutr 2004; 44(2): 128-132.
  26. Lanoir D, Canini F, Messaoudi M, Lefranc C, Demagny B, Martin S, Bourdon L. Long term effects of a bovine milk αs1-casein hydrolysate on healthy low and high stress responders. Stress 2002; 5 (suppl.): 124.
  27. Kim JH, Desor D, Kim YT, Yoon WJ, Kim KS, Jun JS, Pyun KH, Shim I. Efficacy of αs1-casein hydrolysate on stress-related symptoms in women. Eur J Clin Nutr 2007; 61(4): 536-541
  28. Palestrini C, Minero M, Cannas S, Berteselli G, Scaglia E, Barbieri S, Cavallone E, Puricelli M, Servida F, Dall’Ara P. Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs. J Vet Behav 2010; 5(6): 309-317.
  29. Schroeder H, Violle N, Messaoudi M, Lefranc-Millot C, Nejdi A, Demagny B, Desor D. Effects of ING-911, a tryptic hydrolysate from bovine milk alpha-S1casein on anxiety of Wistar male rats measured in the conditioned defensive burying (CDB) paradigm and the elevated plus maze test. Behav Pharmacol 2003; 14 S1: 31
  30. Landsberg G, Milgram B, Mougeot I, Kelly S, de Rivera C. Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat. J Feline Med Surg 2017; 19(6): 594-602.
  31. Kato M, Miyaji K, Ohtanib N, et al. Effects of prescription diet on dealing with stressful situations and performance of anxiety-related behaviors in privately owned anxious dogs. J Vet Behav 2012; 7: 21-26.
  32. Guesdon B, Messaoudi M, Lefranc-Millot C, Fromentin G, Tomé D, Even PC. A tryptic hydrolysate from bovine milk alphaS1-casein improves sleep in rats subjected to chronic mild stress. Peptides 2006; 27(6): 1476-1482.
  33. De la Peña IJI, Kim HJ, De la Peña JB  et al. A tryptic hydrolysate from bovine milk αs1-casein enhances pentobarbital-induced sleep in mice via the GABAA receptor. Behav Brain Res. 2016 Oct 15;313:184-190.
  34. De Saint Hilaire Z, Messaoudi M, Desor D, Kobayashi T. Effects of a bovine αs1-casein tryptic hydrosylate (CTH) on sleep disorder in Japanese general population. The Open Sleep Journal 2009; 2: 26-32.
  35. Kim JH, Kim J, Lee S et al. A Double-Blind, Randomized Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-S1 Casein Hydrolysate on Sleep Disturbance. Nutrients 2019; 11, 1466.
  36. DeNapoli JS, Dodman NH, Shuster L, et al. Effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. J Am Vet Med Assoc 2000; 4: 504-508
  37. Pereira GG, Fragoso S, Pires E. Effect of dietary intake of L-tryptophan supplementation on multi-housed cats presenting stress related behaviours. Proceedings of the British Small Animal Veterinary Association Congress 2010. Birmingham, UK
  38. van Hierden YM, Koolhaas JM, Korte SM. Chronic increase of dietary L-tryptophan decreases gentle feather pecking behavior. Appl Anim Behav Sci 2004; 89: 71-84.
  39. Koopmans SJ, Ruis M, Dekker R, et al. Surplus dietary tryptophan reduces plasma cortisol and noradrenaline concentrations and enhances recovery after social stress in pigs. Physiol Behav 2005; 85: 469-478.
  40. Chamberlain B, Ervin FR, Pihl RO, Young SN. The effect of raising or lowering tryptophan levels on aggression in vervet monkeys. Pharmacol Biochem Behav 1987; 28(4): 503-510.
  41. Data on file (Fibersol)
  42. Rösch C, Venema K, Gruppen H, Schols HA. Characterisation and in vitro fermentation of resistant maltodextrins using human faecal inoculum and analysis of bacterial enzymes present. Bioact Carbohydr 2015; 6(1): 46-53.
  43. Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L. The role of short-chain fatty acids in health and disease. Advances in immunology 2014; 121: 91-119.
  44. SereniCare Fireworks Pet Owner Leaflet References
  45. Blackwell, E., Bradshaw, J., & Casey, R. (2013). Fear responses to noises in domestic dogs: Prevalence, risk factors and co-occurrence with other fear related behaviour. Applied Animal Behaviour Science 145, 15-25.
  46. Dogs figure 62% RSPCA. 2019. Study was conducted in England and Wales via Kantar OnLineBus, an Internet omnibus Survey. A sample of 1,137 adults aged 16+ were interviewed in October 2019. Cats figure 64% 2024 CATS Report. 64% of cat owners say that their cat has been affected by fireworks.
  47. RSPCA. Bang Out of Order. Fireworks Frighten Animals. 2019
  48. Wright AJ, Soto NA, Baldwin AL, Bateson M, Beale CM, Clark C, Deak T, Edwards EF, Fernandez A, Godinho A, Hatch LT, Kakuschke A, Lusseau D, Martineau D, Romero LM, Weilgart LS, Wintle BA, Notarbartolo-di-Sciara G & Martin V (2007) Anthropogenic noise as a stressor in animals: a multidisciplinary perspective. International Journal of Comparative Psychology 20: 250-273
  49. https://www.aaha.org/resources/safe-and-sound-noise-aversion-in-pets/
  50. DeNapoli JS, Dodman NH, Shuster L, et al. Effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. J Am Vet Med Assoc 2000; 4: 504-8
  51. Pereira GG, Fragoso S, Pires E. Effect of dietary intake of L-tryptophan supplementation on multi-housed cats presenting stress related behaviours. Proceedings of the British Small Animal Veterinary Association Congress 2010. Birmingham, UK.
  52. Ceraudo G, Sonia C, Lavinia R, Dell’Osso B, Liliana D. Short-term anxiolytic and pro-hypnotic activity of a tryptic hydrolysate of bovine αs1-casein in patients with anxiety spectrum disorders. Journal of Nutraceuticals and Food Science 2017; 2(2): 1-5.
  53. Beata C, Beaumont-Graff E, Coll V, et al. Effect of alpha-casozepine (Zylkene) on anxiety in cats. J Vet Behav 2007; 2(2): 40-46.
  54. Beata C, Beaumont-Graff E, Diaz C, et al. Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. J Vet Behav 2007; 2(5): 175-183.
  55. Violle N, Messaoudi M, Lefranc-Millot C, Desor D, Nejdi A, Demagny B, Schroeder H. Ethological comparison of the effects of a bovine alpha(s1)-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety. Pharmacol Biochem Behav 2006; 84(3): 517-523.
  56. Messaoudi M, Bresson J-L, Desor D, Lefranc C, Boudier J-F, Paquin P. Anxiolytic-like effects of the milk protein hydrolysate Lactium® in healthy human volunteers. Stress 2002; 5 (suppl.): 124.
  57. Messaoudi M, Lefranc-Millot C, Desor D, Demagny B, Bourdon L. Effect of a tryptic hydrolysate from bovine milk αs1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations. Eur J Nutr 2004; 44(2): 128-132.
  58. Lanoir D, Canini F, Messaoudi M, Lefranc C, Demagny B, Martin S, Bourdon L. Long term effects of a bovine milk αs1-casein hydrolysate on healthy low and high stress responders. Stress 2002; 5 (suppl.): 124.
  59. Kim JH, Desor D, Kim YT, Yoon WJ, Kim KS, Jun JS, Pyun KH, Shim I. Efficacy of αs1-casein hydrolysate on stress-related symptoms in women. Eur J Clin Nutr 2007; 61(4): 536-541
  60. Palestrini C, Minero M, Cannas S, Berteselli G, Scaglia E, Barbieri S, Cavallone E, Puricelli M, Servida F, Dall’Ara P. Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs. J Vet Behav 2010; 5(6): 309-317.
  61. Schroeder H, Violle N, Messaoudi M, Lefranc-Millot C, Nejdi A, Demagny B, Desor D. Effects of ING-911, a tryptic hydrolysate from bovine milk alpha-S1casein on anxiety of Wistar male rats measured in the conditioned defensive burying (CDB) paradigm and the elevated plus maze test. Behav Pharmacol 2003; 14 S1: 31
  62. Kato M, Miyaji K, Ohtanib N, et al. Effects of prescription diet on dealing with stressful situations and performance of anxiety-related behaviors in privately owned anxious dogs. J Vet Behav 2012; 7: 21-26.
  63. Rösch C, Venema K, Gruppen H, Schols HA. Characterisation and in vitro fermentation of resistant maltodextrins using human faecal inoculum and analysis of bacterial enzymes present. Bioact Carbohydr 2015; 6(1): 46-53.
  64. Appleton J. The gut-brain axis: influence of microbiota on mood and mental health. Integr Med (Encinitas) 2018; 17(4): 28-32.
  65. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 2015; 28(2): 203-209.
  66. Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L. The role of short-chain fatty acids in health and disease. Advances in immunology 2014; 121: 91-119.
  67. Home Tester Club, 136 pet owners tried SereniCare for 6 weeks, 2023.

SereniCare Fireworks Pet Owner Leaflet References

  1. Blackwell, E., Bradshaw, J., & Casey, R. (2013). Fear responses to noises in domestic dogs: Prevalence, risk factors and co-occurrence with other fear related behaviour. Applied Animal Behaviour Science 145, 15-25.
  2. Dogs figure 62% RSPCA. 2019. Study was conducted in England and Wales via Kantar OnLineBus, an Internet omnibus Survey. A sample of 1,137 adults aged 16+ were interviewed in October 2019. Cats figure 64% 2024 CATS Report. 64% of cat owners say that their cat has been affected by fireworks.
  3. RSPCA. Bang Out of Order. Fireworks Frighten Animals. 2019
  4. Wright AJ, Soto NA, Baldwin AL, Bateson M, Beale CM, Clark C, Deak T, Edwards EF, Fernandez A, Godinho A, Hatch LT, Kakuschke A, Lusseau D, Martineau D, Romero LM, Weilgart LS, Wintle BA, Notarbartolo-di-Sciara G & Martin V (2007) Anthropogenic noise as a stressor in animals: a multidisciplinary perspective. International Journal of Comparative Psychology 20: 250-273
  5. https://www.aaha.org/resources/safe-and-sound-noise-aversion-in-pets/
  6. DeNapoli JS, Dodman NH, Shuster L, et al. Effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. J Am Vet Med Assoc 2000; 4: 504-8
  7. Pereira GG, Fragoso S, Pires E. Effect of dietary intake of L-tryptophan supplementation on multi-housed cats presenting stress related behaviours. Proceedings of the British Small Animal Veterinary Association Congress 2010. Birmingham, UK.
  8. Ceraudo G, Sonia C, Lavinia R, Dell’Osso B, Liliana D. Short-term anxiolytic and pro-hypnotic activity of a tryptic hydrolysate of bovine αs1-casein in patients with anxiety spectrum disorders. Journal of Nutraceuticals and Food Science 2017; 2(2): 1-5.
  9.  Beata C, Beaumont-Graff E, Coll V, et al. Effect of alpha-casozepine (Zylkene) on anxiety in cats. J Vet Behav 2007; 2(2): 40-46.
  10.  Beata C, Beaumont-Graff E, Diaz C, et al. Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. J Vet Behav 2007; 2(5): 175-183.
  11. Violle N, Messaoudi M, Lefranc-Millot C, Desor D, Nejdi A, Demagny B, Schroeder H. Ethological comparison of the effects of a bovine alpha(s1)-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety. Pharmacol Biochem Behav 2006; 84(3): 517-523.
  12. Messaoudi M, Bresson J-L, Desor D, Lefranc C, Boudier J-F, Paquin P. Anxiolytic-like effects of the milk protein hydrolysate Lactium® in healthy human volunteers. Stress 2002; 5 (suppl.): 124.
  13. Messaoudi M, Lefranc-Millot C, Desor D, Demagny B, Bourdon L. Effect of a tryptic hydrolysate from bovine milk αs1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations. Eur J Nutr 2004; 44(2): 128-132.
  14.  Lanoir D, Canini F, Messaoudi M, Lefranc C, Demagny B, Martin S, Bourdon L. Long term effects of a bovine milk αs1-casein hydrolysate on healthy low and high stress responders. Stress 2002; 5 (suppl.): 124.
  15. Kim JH, Desor D, Kim YT, Yoon WJ, Kim KS, Jun JS, Pyun KH, Shim I. Efficacy of αs1-casein hydrolysate on stress-related symptoms in women. Eur J Clin Nutr 2007; 61(4): 536-541
  16. Palestrini C, Minero M, Cannas S, Berteselli G, Scaglia E, Barbieri S, Cavallone E, Puricelli M, Servida F, Dall’Ara P. Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs. J Vet Behav 2010; 5(6): 309-317.
  17. Schroeder H, Violle N, Messaoudi M, Lefranc-Millot C, Nejdi A, Demagny B, Desor D. Effects of ING-911, a tryptic hydrolysate from bovine milk alpha-S1casein on anxiety of Wistar male rats measured in the conditioned defensive burying (CDB) paradigm and the elevated plus maze test. Behav Pharmacol 2003; 14 S1: 31
  18. Kato M, Miyaji K, Ohtanib N, et al. Effects of prescription diet on dealing with stressful situations and performance of anxiety-related behaviors in privately owned anxious dogs. J Vet Behav 2012; 7: 21-26.
  19. Rösch C, Venema K, Gruppen H, Schols HA. Characterisation and in vitro fermentation of resistant maltodextrins using human faecal inoculum and analysis of bacterial enzymes present. Bioact Carbohydr 2015; 6(1): 46-53.
  20. Appleton J. The gut-brain axis: influence of microbiota on mood and mental health. Integr Med (Encinitas) 2018; 17(4): 28-32.
  21. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 2015; 28(2): 203-209.
  22. Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L. The role of short-chain fatty acids in health and disease. Advances in immunology 2014; 121: 91-119.
  23. Home Tester Club, 136 pet owners tried SereniCare for 6 weeks, 2023.