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SereniCare and Cystophan References – Italy

SereniCare Product Brochure References

  • Data on file: acid stability – Fibersol
  • Chen S, Martirosyan D. FOSHU-approved Fibersol®-2 product review. Bioact Compd Health Dis 2021; 4(5): 79-89.
  • Flickinger EA, Wolf BW, Garleb KA, et al. Glucose-based oligosaccharides exhibit different in vitro fermentation patterns and affect in vivo apparent nutrient digestibility and microbial populations in dogs. J Nutr 2000; 130(5): 1267-73.
  • Rösch C, Venema K, Gruppen H, Schols HA. Characterisation and in vitro fermentation of resistant maltodextrins using human faecal inoculum and analysis of bacterial enzymes present. Bioact Carbohydr 2015; 6(1): 46-53.
  • Appleton J. The gut-brain axis: influence of microbiota on mood and mental health. Integr Med (Encinitas) 2018; 17(4): 28-32.
  • Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 2015; 28(2): 203-209.
  • Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L. The role of short-chain fatty acids in health and disease. Advances in immunology 2014; 121: 91-119.
  • Data on file
  • Gao K, Mu CL, Farzi A, Zhu WY. Tryptophan metabolism: a link between the gut microbiota and brain. Adv Nutr 2020; 11(3): 709-723.
  • Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients 2016; 8(1): 56.
  • Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-tryptophan: basic metabolic functions, behavioral research and therapeutic indications. Int J Tryptophan Res 2009; 2: 45-60.
  • DeNapoli JS, Dodman NH, Shuster L, et al. Effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. J Am Vet Med Assoc 2000; 4: 504-8
  • Pereira GG, Fragoso S, Pires E. Effect of dietary intake of L-tryptophan supplementation on multi-housed cats presenting stress related behaviours. Proceedings of the British Small Animal Veterinary Association Congress 2010. Birmingham, UK.
  • van Hierden YM, Koolhaas JM, Korte SM. Chronic increase of dietary L-tryptophan decreases gentle feather pecking behavior. Appl Anim Behav Sci 2004; 89: 71-84.
  • Koopmans SJ, Ruis M, Dekker R, et al. Surplus dietary tryptophan reduces plasma cortisol and noradrenaline concentrations and enhances recovery after social stress in pigs. Physiol Behav 2005; 85: 469-78.
  • Chamberlain B, Ervin FR, Pihl RO, Young SN. The effect of raising or lowering tryptophan levels on aggression in vervet monkeys. Pharmacol Biochem Behav 1987; 28(4): 503-10.
  • Landsberg G, Milgram B, Mougeot I, Kelly S, de Rivera C. Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat. Journal of Feline Medicine and Surgery 2017; 19(6):594-602.
  • Mohammad-Zadeh LF, Moses L, Gwaltney-Brant SM. Serotonin: a review. Journal of veterinary pharmacology and therapeutics 2008; 31(3):187-99.
  • Lv J, Liu F. The role of serotonin beyond the central nervous system during embryogenesis. Front Cell Neurosci 2017; 11: 74.
  • Kaur H, Bose C, Mande SS. Tryptophan metabolism by gut microbiome and gut-brain-axis: an in silico analysis. Front Neurosci 2019; 13: 1365.
  • Gheorghe CE, Martin JA, Manriquez FV, Dinan TG, Cryan JF, Clarke G. Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis. Curr Opin Pharmacol 2019; 48: 137-145.
  • Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264-76.
  • Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007;132:397-414.
  • Ceraudo G, Sonia C, Lavinia R, Dell’Osso B, Liliana D. Short-term anxiolytic and pro-hypnotic activity of a tryptic hydrolysate of bovine αs1-casein in patients with anxiety spectrum disorders. Journal of Nutraceuticals and Food Science 2017; 2(2): 1-5.
  • Beata C, Beaumont-Graff E, Coll V, et al. Effect of alpha-casozepine (Zylkene) on anxiety in cats. J Vet Behav 2007; 2(2): 40-46.
  • Beata C, Beaumont-Graff E, Diaz C, et al. Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. J Vet Behav 2007; 2(5): 175-183.
  • Violle N, Messaoudi M, Lefranc-Millot C, Desor D, Nejdi A, Demagny B, Schroeder H. Ethological comparison of the effects of a bovine alpha(s1)-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety. Pharmacol Biochem Behav 2006; 84(3): 517-523.
  • Messaoudi M, Bresson J-L, Desor D, Lefranc C, Boudier J-F, Paquin P. Anxiolytic-like effects of the milk protein hydrolysate Lactium® in healthy human volunteers. Stress 2002; 5 (suppl.): 124.
  • Messaoudi M, Lefranc-Millot C, Desor D, Demagny B, Bourdon L. Effect of a tryptic hydrolysate from bovine milk αs1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations. Eur J Nutr 2004; 44(2): 128-132.
  • Lanoir D, Canini F, Messaoudi M, Lefranc C, Demagny B, Martin S, Bourdon L. Long term effects of a bovine milk αs1-casein hydrolysate on healthy low and high stress responders. Stress 2002; 5 (suppl.): 124.
  • Kim JH, Desor D, Kim YT, Yoon WJ, Kim KS, Jun JS, Pyun KH, Shim I. Efficacy of αs1-casein hydrolysate on stress-related symptoms in women. Eur J Clin Nutr 2007; 61(4): 536-541
  • Palestrini C, Minero M, Cannas S, Berteselli G, Scaglia E, Barbieri S, Cavallone E, Puricelli M, Servida F, Dall’Ara P. Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs. J Vet Behav 2010; 5(6): 309-317.
  • Schroeder H, Violle N, Messaoudi M, Lefranc-Millot C, Nejdi A, Demagny B, Desor D. Effects of ING-911, a tryptic hydrolysate from bovine milk alpha-S1casein on anxiety of Wistar male rats measured in the conditioned defensive burying (CDB) paradigm and the elevated plus maze test. Behav Pharmacol 2003; 14 S1: 31
  • Kato M, Miyaji K, Ohtanib N, et al. Effects of prescription diet on dealing with stressful situations and performance of anxiety-related behaviors in privately owned anxious dogs. J Vet Behav 2012; 7: 21-26.
  • Home Tester Club, 136 pet owners tried SereniCare for 6 weeks, 2023.

Cystophan Product Brochure References

  • Bolla SR, Odeluga N, Amraei R, Jetti R. Histology, bladder. In: StatPearls [Internet]. StatPearls Publishing, 2023.
  • Beckel JM, Holstege G. Neuroanatomy of the lower urinary tract. Handb Exp Pharmacol 2011; 202: 99-116.
  • Klingler CH. Glycosaminoglycans: how much do we know about their role in the bladder? Urologia 2016; 83(Suppl 1): 11-14.
  • Gunn-Moore DA, Shenoy CM. Oral glucosamine and the management of feline idiopathic cystitis. J Fel Med Surg 2004; 6(4): 219-25.
  • Parsons CL. The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. BJU international 2011; 107(3):370-5.
  • Stott C, Fairbrother G. Mucus and urinary diversions. World Council of Enterostomal Therapists Journal. 2015 Oct;35(4):36-41.
  • Panchaphanpong J, Asawakarn T, Pusoonthornthum R. Effects of oral administration of N-acetyl-d-glucosamine on plasma and urine concentrations of glycosaminoglycans in cats with idiopathic cystitis. Am J Vet Res 2011; 72(6): 843-50.
  • Stellavato A, Pirozzi AVA, Diana P, et al. Hyaluronic acid and chondroitin sulfate, alone or in combination, efficiently counteract induced bladder cell damage and inflammation. PloS One 2019; 14(6): e0218475.
  • Serretta V, Di Maida F, Scalici Gesolfo C, et al. The activity of intravesical hyaluronic acid and chondroitin sulfate administration on urothelial gene expression. Preliminary results on the epidermal growth factor receptor and fibronectin gene expression evaluated in bladder washings of patients affected by non muscle-invasive bladder cancer. InAbstracts 32nd Annual EAU Congress 2017.
  • De Klerk DP. The glycosaminoglycans of human bladder cancers of varying grade and stage. The Journal of urology. 1985; 134(5):978-81
  • Khastgir J. Intravesical GAG replacement therapies for bladder pain syndrome/interstitial cystitis – an update. Urology News 2020; 24
  • Rooney P, Srivastava A, Watson L, Quinlan LR, Pandit A. Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis. Acta Biomater 2015; 19: 66-75.
  • Westropp JL, Kass PH, Buffington CT. Evaluation of the effects of stress in cats with idiopathic cystitis. Am J Vet Res 2006; 67(4): 731-6.
  • Naarden B, Corbee RJ. The effect of a therapeutic urinary stress diet on the short-term recurrence of feline idiopathic cystitis. Vet Med Sci 2020; 6(1): 32-8.
  • Forrester SD, Towell TL. Feline idiopathic cystitis. Vet Clin North Am Small Anim Pract. 2015 Jul; 45(4):783-806.
  • Landsberg G, Milgram B, Mougeot I, Kelly S, de Rivera C. Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat. Journal of Feline Medicine and Surgery 2017; 19(6):594-602.
  • Mohammad-Zadeh LF, Moses L, Gwaltney-Brant SM. Serotonin: a review. Journal of veterinary pharmacology and therapeutics 2008; 31(3):187-99.
  • Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients 2016; 8(1): 56.
  • Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-tryptophan: basic metabolic functions, behavioral research and therapeutic indications. Int J Tryptophan Res 2009; 2: 45-60.
  • Lv J, Liu F. The role of serotonin beyond the central nervous system during embryogenesis. Front Cell Neurosci 2017; 11: 74.
  • Gao K, Mu CL, Farzi A, Zhu WY. Tryptophan metabolism: a link between the gut microbiota and brain. Adv Nutr 2020; 11(3): 709-23.
  • DeNapoli JS, Dodman NH, Shuster L, et al. Effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. J Am Vet Med Assoc 2000; 4: 504-8
  • Pereira GG, Fragoso S, Pires E. Effect of dietary intake of L-tryptophan supplementation on multi-housed cats presenting stress related behaviours. Proceedings of the British Small Animal Veterinary Association Congress 2010. Birmingham, UK.
  • van Hierden YM, Koolhaas JM, Korte SM. Chronic increase of dietary L-tryptophan decreases gentle feather pecking behavior. Appl Anim Behav Sci 2004; 89: 71-84.
  • Koopmans SJ, Ruis M, Dekker R, et al. Surplus dietary tryptophan reduces plasma cortisol and noradrenaline concentrations and enhances recovery after social stress in pigs. Physiol Behav 2005; 85: 469-78.
  • Chamberlain B, Ervin FR, Pihl RO, Young SN. The effect of raising or lowering tryptophan levels on aggression in vervet monkeys. Pharmacol Biochem Behav 1987; 28(4): 503-10.