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Protexin CogniCare Literature References

References

  1. Vitturini, C. et al. Diagnosis of Canine Cognitive Dysfunction Syndrome: A Narrative Review. Vet. Sci. 2025;12, 781.
  2. Blanchard, T. et al. Enhancing cognitive functions in aged dogs and cats:
    a systematic review of enriched diets and nutraceuticals. GeroScience 2025; 47, 2925-2947.
  3. Sacoor, C. et al. Gut-Brain Axis Impact on Canine Anxiety Disorders: New
    Challenges for Behavioural Veterinary Medicine. Vet Med Int. 2024: https://doi.org/10.1155/2024/2856759
  4. Landsberg, GM. et al. Cognitive dysfunction syndrome: a disease of canine and feline brain aging. Vet Clin North Am Small Anim Pract 2012; 42:749–768.
  5. Pan, Y. et al. Cognitive enhancement in middle-aged and old cats with dietary supplementation with a nutrient blend containing fish oil, B vitamins, antioxidants and arginine. British Journal of Nutrition 2013; 110, 40–49.
  6. Pan, Y. et al. Cognitive enhancement in old dogs from dietary supplementation with a nutrient blend containing arginine, antioxidants, B vitamins and fish oil. British Journal of Nutrition 2018; 119, 349–358.
  7. Azkona, G. et al. Prevalence and risk factors of behavioural changes associated with age-related cognitive impairment in geriatric dogs.
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  8. Neilson JC. et al. Prevalence of behavioural changes associated with age-related cognitive impairment in dogs. J Am Vet Med Assoc 2001; 218, 1787–1791.
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  10. Gunn-Moore DA. Cognitive dysfunction in cats: clinical assessment and management. Top Companion Anim Med 2011; 26: 17–24.
  11. Sordo, L. et al. Cognitive Dysfunction in Cats: Update on Neuropathological and Behavioural Changes Plus Clinical Management. Vet Record 2021; 188, e3. https://doi.org/10.1002/vetr.3
  12. Haake, J. et al. Comparing standard screening questionnaires of canine behavior for assessment of cognitive dysfunction. Front. Vet. Sci. 2024; 11:1374511. doi: 10.3389/fvets.2024.1374511
  13. Ehrenzweig, J. et al. Canine cognitive decline and Alzheimer disease: clinical insights to solve a shared one-health problem. JAVMA 2023; 261: 11, 1597-1604.
  14. Kang, M-H. et al. Cognitive dysfunction in aging dogs and cats: diagnosis and management perspectives. J Vet Sci. 2025; 26(S1): S125-S138.
  15. May, KA. et al. Nutrition and the aging brain of dogs and cats. JAVMA 2019; 255,11, 1245-1254.
  16. Ansari, F. et al. The role of probiotics and prebiotics in modulating of the gut-brain axis. Front. Nutr. 2023; 10:1173660. doi: 10.3389/fnut.2023.1173660
  17. Gao, K. et al. Tryptophan metabolism: a link between the gut microbiota and brain. Adv Nutr 2020; 11(3): 709-723
  18. Lim, JR et al. Anti-aging strategies for dogs: current insights and future directions. J Vet Sci. 2025; 26(S1): S199-S219.
  19. Zhao, M. et al. Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review. Biomedicine & Pharmacotherapy 2023; 164 114985.
  20. Schmid, SM et al. The companion dog as a model for inflammaging: a cross-sectional pilot study. GeroScience (2024) 46:5395–5407. https://doi.org/10.1007/s11357-024-01217-w
  21. Fernández-Pinteño, A. et al. Age-Related Changes in Gut Health and Behavioural Biomarkers in a Beagle Dog Population. Animals 2025; 15, 234. https://doi.org/10.3390/ani15020234
  22. Guelfi, G. et al. Dog Aging: A Comprehensive Review of Molecular, Cellular, and Physiological Processes. Cells 2024; 13, 2101. https://doi.org/10.3390/cells13242101
  23. Kubinyi, E. Gut Microbiome Composition is Associated with Age and Memory Performance in Pet Dogs. Animals 2020; 10(9), 1488; https://doi.org/10.3390/ani10091488
  24. Slavin, J. Fiber and prebiotics: mechanisms and health benefits. Nutrients 2013; 5(4): 1417-3518,19.
  25. Perini, MP. et al. Potential effects of prebiotics on gastrointestinal and immunological modulation in the feeding of healthy dogs: a review. Fermentation 2023; 9(7): 693.
  26. Tan, J. et al. The role of short-chain fatty acids in health and disease. Adv Immunol 2014; 121: 91-119.
  27. Jalanka, J et al. The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls. Int J Mol Sci 2019; 20(2):433.
  28. Data on file – acid stability.
  29. Chen, S. et al. FOSHU-approved Fibersol-2 product review. Bioact Compd Health Dis 2021; 4(5): 79-89.
  30. Flickinger, EA et al. Glucose-based oligosaccharides exhibit different in vitro fermentation patterns and affect in vivo apparent nutrient digestibility and microbial populations in dogs. J Nutr.2000; 130(5): 1267-73.
  31. Saral, B et al. An exploratory study of behavioural, cognitive, physiological, and microbiota profiles in senior dogs. Front. Behav. Neurosci. 2026; 20:1689807. doi: 10.3389/fnbeh.2026.1689807.
  32. Jia, L et al. Postbiotics alleviate cognitive impairment and neuroinflammation via gut-brain axis and TLR4/MyD88/NLRP3 pathway. Food Res Int 2025; 222: 2.
  33. Robles, V et al. The Effect of the Combination of Two Postbiotics on Anxiety-like Behaviour in Animal Models. Cells 2024; 13, 2006. https://doi.org/10.3390/cells13232006
  34. Wang, F et al. Effects of Heat-Treated Bifidobacterium longum CECT-7347 Combined with Fibersol-2 on the Intestinal Health of Cats Submitted to an abrupt Dietary Change: A Randomized Controlled Study. Animals 2024; 14, 2179.
  35. Paris, S et al. Beta-glucan-induced trained immunity in dogs. Front Immunol 2020; 11: 566893.
  36. Haladová, E. et al. Immunomodulatory effect of glucan on specific and non-specific immunity after vaccination in puppies. Acta Vet Hung 2011; 59(1): 77-86.
  37. Stuyven, E. et al. Oral administration of 1,3/1,6 -glucan to dogs temporarily changes total and antigen-specific IgA and IgM. Clin Vacc Immunol 2010; 17(2): 281-285.
  38. Pawar, MM et al. Effect of dietary mannan-oligosaccharide supplementation on nutrient digestibility, hindgut fermentation, immune response and antioxidant indices in dogs. J Anim Sci Technol 2017; 59: 1-7.
  39. Lin, CY et al. Supplementation of yeast cell wall fraction tends to improve intestinal health in dogs undergoing an abrupt diet transition. Front Vet Sci 2020; 7: 597939.
  40. Newman, KE et al. Evaluation of mannan-oligosaccharide on the microflora and immunoglobulin status of sows and piglet performance. J Anim Sci 2001; 79: 189-191.
  41. Spring, P et al. A review of 733 published trials on Bio-Mos, a mannan-oligosaccharide, and Actigen, a second-generation mannose-rich fraction, on farm and companion animals. J Appl Anim Nutr 2015; 3: e8.
  42. Gouveia, EM et al. Use of mannan-oligosaccharides as an adjuvant treatment for gastrointestinal diseases and their effects on E. coli inactivated in dogs. Acta Cir Bras 2006; 21(4): 23-26.
  43. Marchi, PH et al. Effects of Increasing Levels of Purified Beta-1,3/1,6-Glucans on the Fecal Microbiome, Digestibility, and Immunity Variables of Healthy Adult Dogs. Microorganisms 2024; 12, 113.
  44. Osella, MC et al. Phosphatidylserine (PS) as a potential nutraceutical for canine brain aging: A review. J Vet Behav. 2008; 3(2): 41-51.
  45. Umekar M et al. Vitamin B12 deficiency and cognitive impairment: A comprehensive review of neurological impact. Brain Disorders 2025; 18: 100220.
  46. Dor, C et al. Efficacy and tolerance of oral versus parenteral cyanocobalamin supplement in hypocobalaminaemic dogs with chronic enteropathy: a controlled randomised open-label trial. JSAP (2024);65, 317–328.
  47. Head, E et al. Oxidative Stress, Aging and CNS disease in the Canine Model of Human Brain Aging. Vet Clin North Am Small Anim Pract. 2008 Jan; 38(1):167–vi.
  48. Pervin, M et al. L-Arginine Exerts Excellent Anti-Stress Effects on Stress-Induced Shortened Lifespan, Cognitive Decline and Depression. Int. J. Mol. Sci. 2021; 22, 508.
  49. Araujo JA et al. Sphingolipids and DHA Improve Cognitive Deficits in Aged Beagle Dogs. Front. Vet. Sci. 2022; 9:646451. doi: 10.3389/fvets.2022.646451.
  50. Martorell, P et al. Heat-treated Bifidobacterium longum CECT-7347: a whole-cell postbiotic with antioxidant, anti-inflammatory and gut-barrier protection properties. Antioxidants (Basel) 2021; 10(4): 536.